Overall, these results support development of clinical trials evaluating mebendazole for ovarian cancer treatment. Treatment results of juvenile pilocytic astrocytoma. 1995 Feb 15;75(4):1051-9. Mebendazole is used to treat parasitic infections and may slow the growth of tumor cells by interfering with cell structure and preventing new tumor blood vessels from forming. With regard to HCC Mebendazole has been found to be effective in vitro system of HCC and preclinical models. Epub 2006 Jul 19. Similarly, the anti-malarial compound chloroquine showed surprising properties in combating cancer and tumor growth in a series of experiments led by a group at the University of Kentucky. 1998 Jul;89(1):52-9. Paraskevopoulos D, Patsalas I, Karkavelas G, Foroglou N, Magras I, Selviaridis P. Pilomyxoid astrocytoma of the cervical spinal cord in a child with rapid progression into glioblastoma: case report and literature review. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells. This is a phase I/II study of mebendazole in combination with standard of care agents for pediatric patients with gliomas. 2005;56(1):191. Carboplatin will be administered intravenously on Day 1 of Weeks 0,1,2,3 of the 10-week Induction cycle, and on Day 1 of Weeks 0,1,2,3 during the six 10-week maintenance cycles. The clinical trials on this list are for ovarian cancer. Mebendazole is a drug used to treat infections with intestinal parasites and has a long track record of safety in humans. Anticancer Res. Low-grade glioma patients only. J Child Neurol. However, tumors which are only partially resected and continue to grow or cause symptoms, or those which recur following total resection require additional treatment, such as chemotherapy. Low-grade gliomas are tumors arising from the glial cells of the central nervous system and are characterized by slower, less aggressive growth than that of high-grade gliomas. Wallner KE, Gonzales MF, Edwards MS, Wara WM, Sheline GE. J Neurosurg. A secondary end point is to determine if MBZ wit… All trials on the list are supported by NCI. Clinical trials are research studies that involve people. J Neurosurg. U.S. Department of Health and Human Services. Bevacizumab will be administered intravenously on Days 1 and 15 of each maintenance cycle. Wisoff JH, Boyett JM, Berger MS, Brant C, Li H, Yates AJ, McGuire-Cullen P, Turski PA, Sutton LN, Allen JC, Packer RJ, Finlay JL. Vincristine will be dosed as per the following: For patients < 12kg: 0.05 mg/kg; for patient > 12kg: 1.5mg/m2 (maximal dose 2.0 mg). Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma. 2001 Nov 1;51(3):704-10. Mebendazole is a drug used to treat infections with intestinal parasites and has a long track record of safety in humans. Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR, et al. Clin Cancer Res. Patients with high-grade gliomas and diffuse intrinsic pontine gliomas will receive a regimen of mebendazole in combination with bevacizumab and irinotecan. Gliomas of the anterior visual pathway. Optic pathway and hypothalamic/chiasmatic gliomas in children younger than age 5 years with a 6-year follow-up. Temozolomide will be given orally for 5 days during Week 6 of the 10-week induction cycle and for 5 days during Week 6 of the six 10-week maintenance cycles. Epub 2006 Jun 30. Review. One is a Phase I open label study, at John Hopkins Hospital, of MBZ in newly diagnosed high-grade glioma patients receiving temozolomide (http://clinicaltrials.gov/ct2/show/NCT01729260). Ceppa EP, Bouffet E, Griebel R, Robinson C, Tihan T. The pilomyxoid astrocytoma and its relationship to pilocytic astrocytoma: report of a case and a critical review of the entity. Negative pregnancy test in women of childbearing potential within 7 days of initiating investigational therapy. 1998 Oct;79(4):334-8. Bauman G, Lote K, Larson D, Stalpers L, Leighton C, Fisher B, Wara W, MacDonald D, Stitt L, Cairncross JG. There are rarely any side effects. Int J Radiat Oncol Biol Phys. Please remove one or more studies before adding more. Following completion of therapy, patients will continue to be monitored by MRI to assess progression-free and overall-survival. Indeed, there are case reports published in peer review papers showing that Mebendazole can induce anti-cancer response in some aggressive cancers. Anti-helminthic drugs belonging to imidazoles/benzimidazoles class of drugs like albendazole, fenbendazole, or mebendazole, all have shown some anti-cancer activity in various clinical trials. Friedman HS, Krischer JP, Burger P, Oakes WJ, Hockenberger B, Weiner MD, Falletta JM, Norris D, Ragab AH, Mahoney DH Jr, et al. The standard therapy is radiation therapy. Lactating females must agree they will not breastfeed a child while on this study. It is less than 0.05% soluble in water, dilute mineral acid solutions, alcohol, ether and chloroform, but is soluble in formic acid. Am J Gastroenterol. 2.2 Group B - High-grade Glioma/Pontine Glioma Group: Patients with primary spinal cord malignant gliomas are eligible. Packer RJ, Ater J, Allen J, Phillips P, Geyer R, Nicholson HS, Jakacki R, Kurczynski E, Needle M, Finlay J, Reaman G, Boyett JM. Study record managers: refer to the Data Element Definitions if submitting registration or results information. This phase I clinical trial studies the side effects and best dose of mebendazole in treating patients with pediatric brain tumors that have come back (recurrent) or have not responded to treatment (refractory). Patients with relapsed low-grade gliomas who have been previously treated with chemotherapy will be eligible for the study provided they have not previously failed therapy with any of the chemotherapeutic agents used in this study. Finlay JL, Wisoff JH. Lefkowitz IB, Packer RJ, Sutton LN, Siegel KR, Bruce DA, Evans AE, Schut L. Results of the treatment of children with recurrent gliomas with lomustine and vincristine. Previously, we discussed on this website the anti-worm drug Mebendazole (Ref. Neurosurgery. Pediatr Neurosurg. Doudican N, Rodriguez A, Osman I, Orlow SJ. The study will be amended for the maximally tolerated dose for each group to be used in the remainder of the study. The percentage of patients demonstrating a partial (greater than 50% decrease in tumor volume in 3 dimensions) or complete response on MRI in patients with low-grade gliomas treated with mebendazole in combination with vincristine, carboplatin and temozolomide after surgical resection, to the extent feasible. Mebendazole Elicits a Potent Antitumor Effect on Human Cancer Cell Lines Both in Vitro and in Vivo, Tapas Mukhopadhyay,Ji-ichiro Sasaki,Rajagopal Ramesh, and Jack A. Roth, Clinical Cancer Research September 2002 8; 2963 Mol Cancer Res. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01837862. 1999 Nov 1;45(4):923-9. Cancer. High grade gliomas are more aggressive tumors with poor prognoses. Sievert AJ, Fisher MJ. The clinical trials on this list are studying Mebendazole. Conway PD, Oechler HW, Kun LE, Murray KJ. Optic pathway gliomas and diffuse intrinsic pontine gliomas may remain unresected. Cancer. Pretreatment factors predict overall survival for patients with low-grade glioma: a recursive partitioning analysis. Cancer. Clinical trials look at new ways to prevent, detect, or treat disease. It is easy to use, and there aren’t any scary side effects. It is used to treat infections caused by worms. Patients who have previously had a severe side effect, such as agranulocytosis and neutropenia, in conjunction with previous mebendazole or benzimidazole class drug for a parasitic infection . Clearly Fenbendazole is the better drug. This is a study to determine the safety and efficacy of the drug, mebendazole, when used in combination with standard chemotherapy drugs for the treatment of pediatric brain tumors. Irinotecan will be administered at doses 125 mg/m2, 150 mg/m2, 250 mg/m2, or 300 mg/m2, depending on patient tolerance and concomitant enzyme-inducing anti-epileptic medication use. In facilities where there are a lot of rodents, pinworms are a common problem. Mamelak AN, Prados MD, Obana WG, Cogen PH, Edwards MS. 2009 Nov;24(11):1397-408. doi: 10.1177/0883073809342005. We understand that colorectal cancer is a very personal condition, and every patient is unique. The key hallmark features of HCC include activation of MAPK and angiogenesis which in turn are targeted by RTK inhibitors such as Sorafenib and Lenvatinib. Approach: Riggins and Gallia are using mebendazole, a drug in the family of compounds that includes fenbendazole, a veterinary antiparasitic that had serendipitously been discovered to prevent tumor growth in lab mice. J Neurosurg. Patients who have known allergy to mebendazole or benzimidazole class drugs. Low-grade glioma patients only. 1983 Sep;78(9):584-8. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. ( 50 mg/kg/day, 100 mg/kg/day, or treat disease is to determine this combinations safety and scientific of! 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